Abstract
Summary
The administration of phenobarbital to rats bearing a pituitary mammotropic tumor (MtT) produced an increase in the hepatic metabolism of hexobarbital which was greater than that of similarly treated control rats. The formation of formaldehyde from aminopyrine by liver from MtT-bearing rats, however, was not increased by an amount comparable to that of control rats following phenobarbital pretreatment. The metabolism of benzpyrene was increased more than that of zoxazolamine by liver from MtT rats after an injection of 3-MC, and the metabolism of both compounds was increased more than that found after control rats were injected with 3-MC. An increase in the liver metabolism of four drugs which followed phenobarbital or 3-MC pretreatment of control rats, therefore, was not prevented by growth in rats of a corticotropin, somatotropin, and prolactin producing pituitary tumor.
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