Abstract
Summary
The nature of antibody globulins produced by rabbits immunized with heat-killed Candida albicans was investigated. Most of the antibodies were directed against a cell wall antigen rich in mannan. The agglutinin activity of immune serum, purified IgG, and a preparation highly enriched in IgM could be removed by absorption with mannan. In addition, when the IgM-containing preparation was reduced with 2-ME and alkylated, antibody activity was lost. We concluded that the rabbit makes antibodies of the IgG and IgM classes in response to intravenous injections of killed Candida albicans.
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