Abstract
Summary
The presence of DOOTC, as well as MOTC, DMCT, and TC, in inflammation exudate within the granuloma pouch demonstrated that these tetracyclines can pass from the blood into localized areas of inflammation. In addition, unbound concentrations of DOOTC and the other antibiotic were generally greater than the MIC values for bacteria commonly associated with suppurative disease. One could readily presume effective antimicrobial chemotherapy under the condition of these modified physiological conditions. The DOOTC appeared in the inflammation exudate more rapidly, to a greater concentration, and persisted longer than did the other antibiotics studied.
Get full access to this article
View all access options for this article.