Abstract
Summary
Studies of in vitro binding of barbiturates by rat hepatic subcellular fractions were performed to relate differences in substrate-protein interaction to alterations in drug metabolism. Binding of pentobarbital and phenobarbital by the microsomal fraction was tenfold greater than that of barbital. The microsomal fraction also exhibited an age dependent increase in binding per unit of protein, but no differences were found between sexes, or following phenobarbital pre-treatment.
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