Abstract
Summary
The active material found in horse placental fluids which inhibits the hemagglutination of H-1 and HB viruses has been purified, and a homogeneous product obtained as shown by disc electrophoresis. The inhibitor sediments in a sucrose gradient as a macroglobulin that can be rendered inactive by treatment with papain, neuraminidase, or sodium metaperiodate. Though a similar inhibitor is found in human placental fluids, the two substances are not identical. The purified material from the horse placental fluids shows a remarkable capacity for inhibiting hemagglutination by H-1 virus since it is active in concentrations as low as 0.006 μg/ml.
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