Abstract
Summary
Reticuloendothelial cell blockade has been used to study the possible role of phagocytic cells in the primary immune response of mice to S-RBC. Administration of colloidal carbon (10 mg per mouse) resulted in a marked suppression in appearance of normal numbers of antibody plaque forming cells to S-RBC in the spleens of treated mice. There was a suppression in both the total number of pfc in the spleen and the amount of pfc per million viable nucleated cells. However, the day of peak antibody response was the same for carbon treated mice as for controls. Administration of carbon 24-48 hours prior to injection of S-RBC resulted in the greatest suppression, as compared to treatment on the same day as immunization. Injection of carbon 1-2 days following immunization had little effect on subsequent appearance of plaque forming cells.
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