Abstract
Summary
The histamine releasing property of compound 48/80 has been studied in a variety of tissues and species. In vivo and in vitro studies in the experimental animal have shown effects of compound 48/80 on tissue mast cells and basophiles. The only studies in man have involved intradermal skin testing. The present report indicates that suspensions of human peripheral leukocytes affords a system for studying in vitro histamine release by compound 48/80 in man. There is no difference in the response of atopic and nonatopic subjects.
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