A Difference in Erythropoietin Production between Anemic and Hypoxic Mice ∗

Abstract

Summary

A strain difference in the response to hypoxia of the CAF₁ and CF₁ mice is described. The CF₁ strain developed significant erythropoietin production in response to hypoxia, and after 3 weeks marked polycythemia. In the CAF₁ mouse both erythropoietin production and polycythemia were minimal. Both strains produced comparable amounts of erythropoietin in response to post-hemorrhagic or hemolytic anemia. The implications of these differences are discussed.