Abstract
Summary
Potent inducers of drug-metabolizing enzymes such as phenobarbital and chlorcyclizine are as effective in fed and in starved adult mice as they are in weanling mice maintained on 8 or 27% casein diets. Weaker enzyme inducers such as hexobarbital, antipyrine, or metronidazole are more effective agents in starved adults and weanling mice than they are in the well-fed adult mice. Compounds such as 3, 4-benzpyrene which do not induce increased hexobarbital-metabolizing activity in adult mice are capable of inducing such activity in weanling mice.
Get full access to this article
View all access options for this article.