Hepatic Deposition of 131 I Labeled Amylase in Dogs

Abstract

Summary

After the intravenous injection of amylase ¹³¹I into dogs, the results are similar to those observed after the injection of unlabeled enzyme. With amylase ¹³¹I, isotopic and enzymatic measurements indicate that the enzyme is deposited in the liver. This is accompanied by a decrease in liver glycogen, an increase in muscle glycogen, and hyperglycemia. These changes are not observed in dogs whose reticuloendothelial system (RES) is blockaded by thorium dioxide. This and other evidence suggest that the RES plays an important role in the regulation of the serum concentrations of amylase and in its deposition in the liver. The role of amylase in liver glycogenolysis remains obscure for reasons which are discussed.