Abstract
Summary
The DBA/2 mice infected with Friend leukemia virus and maintained on a thiamine-free diet showed no histologic evidence or clinical manifestations of leukemia compared with counterpart controls maintained on a normal diet. Aliquot groups originally thiamine-deprived and subsequently refed thiamine developed gross splenomegaly and histologic evidence of leukemia. Similarities in preparation of materials from shellfish extracts in experiments to produce a “thiaminase,” ichthiamin, and those used in antineoplastic experiments suggest a correlation in mechanism of action: thiamine inhibition.
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