Abstract
Summary
The growth of HeLa cells was strongly inhibited by 2%, L-cells by 3%, and E. coli (in broth) by 12% DMSO. The growth of Mengo virus in L-cells, and bacteriophage T4 in E. coli was markedly inhibited by similar concentrations of DMSO. In vitro studies showed that DMSO slightly increased RNase and β-galactosidase activity and markedly decreased that of glycerol dehydrogenase. It is suggested that the in vivo effects of DMSO are primarily due to its ability to alter enzyme reaction rates.
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