Hemodynamic Effects of Prostaglandins E 1,A 1 and F 2 α in Dogs ∗

Abstract

Summary

The cardiovascular effects of PGE₁, PGA₁, and PGFF₂α were studied in anesthetized, open chest dogs. It was found that PGE₁, PGA₁, and PGFF₂α decrease left atrial pressures, and increase heart rate, pulmonary arterial pressure, cardiac output, and myocontractile force. However, both PGE₁ and PGA₁ are vaso-dilators and decrease systemic arterial pressure. The multiple hemodynamic changes induced by the three prostaglandins are caused, not only by their direct effect on the peripheral vasculatures, but also by their effects on the myocardium.