Effects of Prostaglandins E 1,A 1 and F 2α on the Coronary and Peripheral Circulations ∗

Abstract

Summary

The effects of PGE₁, PGA₁, and PGF_2α on the coronary and peripheral circulations were studied in anesthetized dogs. The ia injection of either PGE₁ or PGA₁ increases blood flows and decreases the peripheral resistances in the coronary, brachial, femoral, carotid, and renal arteries. On the other hand, PGF_2α decreases blood flows and increases peripheral resistance in the brachial, femoral, and renal arteries. The present study indicates that PGE₁, and PGA₁ dilate and PGF_2α constricts directly the regional blood vessels.