Abstract
Summary
Rats having permanent gastric fistulas were infused intravenously for 24 hours with calcium in saline, or with saline alone. Gastric secretion was collected for the period of infusion. In calcium-treated rats significant reduction of gastric acid secretion was found. In these animals blood pepsinogen was increased but gastric tissue pepsinogen was reduced. Reduction of zymogenic granules of chief cells was also found in glandular mucosa of calcium-infused rats. Hypercalcemia appeared to alter the function of both parietal and chief cells of rat stomach under the conditions of this experiment.
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