Abstract
Summary
An avian leukosis virus (ALV) free primary yellow fever vaccine seed has been developed by ridding the 17D virus vaccine seed of its ALV contaminant. By differential filtration through Millipore membrane filters of different pore sizes, yellow fever virus was separated from its contaminant by physical means. The ALV could not be detected in the new primary and secondary vaccine seeds by RIF, COFAL, and FAB tests.
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