Abstract
Summary
Virus production was induced by low temperature treatment of the “virus-free” form of the frog renal adenocarcinoma (Lucké tumor). Virus recovered after this low temperature treatment fulfilled the morphological requirements of herpesvirus. Herpesvirus development was also induced in eye chamber transplants from these “virus-free” primary tumors. Results indicate that the two naturally-occurring seasonal forms of this tumor are temperature-related states of the same tumor and suggest that the “virus-free” tumor contains a relatively complete viral genome in masked or latent form.
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