Biliary Excretion of Phenol 3,6-Dibromphthalein Disulfonate in Rats Fed a Protein-Free Diet ∗

Abstract

Summary

Phenol 3,6-dibromphthalein disulfonate (diBSP) was shown to be excreted rapidly in the bile of rats as the unconjugated compound, confirming earlier observations of Javitt (6). In addition, it was demonstrated that diBSP and BSP share common hepatic transport systems. Finally, feeding a protein-free diet for 2 days did not affect the biliary excretion of diBSP, whereas the same diet was previously shown to result in decreased BSP excretion into bile accounted for by diminished excretion of conjugated BSP. The present findings support earlier conclusions that conjugation of BSP is an important determinant of the maximal rate of biliary excretion of BSP.