Abstract
Summary
In man, repeated injections of reserpine result in an initial increase followed by a decrease in the urinary excretion of VMA. Within 16 hours following injection of 2.5 mg of reserpine at 8-hour intervals, increased VMA excretion has ended and there is a continual decrease in the excretory rate. It is suggested that the observed VMA excretory pattern is consistent with a reserpine effect on the intracellular storage granule with an initial release of NE associated with a decreased uptake of dopamine and resultant decreased NE synthesis.
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