Antigenic Enhancement of Ether-Extracted Influenza Virus Vaccines by AlPO 4 ∗

Abstract

Summary

Virus vaccines with AlPO₄, HA vaccines and HA vaccines with AlPO₄ were prepared as monovalent suspensions using 4 strains of influenza A and 2 of influenza B. In all cases, dilutions of the HA vaccines induced lower antibody levels and lower levels of immunity than their virus counterparts. Addition of AlPO₄ restored the antigenicity of HA vaccines to levels almost equal to those of whole virus vaccines. The significance of these findings is briefly discussed.