Abstract
Summary
Aflatoxin inhibits mitosis and causes breakage and translocations in the chromosomes of cultured human leukocytes. The nonrandom pattern of breakage was confined mainly to the largest chromosomes of the human complement. Chromosome no's. 1 and 2 were particularly affected, while groups E, F, and G exhibited a lower than expected frequency of breaks.
The effect of aflatoxin on human leukocytes is of the delayed type which is characteristic of chromosome breaking compounds such as alkylating agents 11 , 12 .
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