Abstract
Summary
The hyperglycemic effect of diazoxide, hydrocortisone, epinephrine, glucagon, and mannoheptulose was studied in Sprague-Dawley rats maintained on a low potassium diet for 25 days, or on a control diet. The low potassium diet produced a hypokalemic, hypochloremic, metabolic alkalosis. There were increased glycogen levels in both liver and muscle with the low potassium diet compared to controls. Diazoxide and hydrocortisone produced an increased hyperglycemic effect in the potassium deficient animals.
The response to mannoheptulose, glucagon, and epinephrine was identical in control and potassium depleted groups. The significance of these results is discussed.
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