Abstract
Summary
Daily subcutaneous injections of 20 mg of yohimbine-HCl per kg of body weight from the 15th day of gestation until parturition increases the length of pregnancy in the rat by 1 day. A single injection of yohimbine on day 20 of pregnancy was without effect on gestation length. Rats which were treated with a daily dose of 20 mg of yohimbine per kg (started on day 15 and sacrified on day 21 of gestation) had significant increased pituitary and adrenal weights as well as smaller fetuses and placentas. Cold stress did not affect the weight of the fetuses or placentas. No difference in growth rate was produced by either yohimbine-HCl or formalin injections.
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