Abstract
Summary
A renal evaluation of a series of aminoalkylureas administered orally to male rats disclosed several compounds with diuretic activity, the most potent of which (P-275) was studied in some detail. When administered intravascularly to dogs, P-275 was without effect on glomerular filtration and renal plasma flow while sodium and water excretion was either only transiently or moderately elevated. Oral administration to dogs produced Na+ and water diuresis in males. Removing the ovaries induced responsiveness in the female while treatment of the male with estrogen produced a reversible refractoriness to the saluretic effect of this compound. Testosterone treatment failed to overcome the refractory state to P-275 in the intact female. These findings plus the results from an isolated clinical case with the chemical congener, P-286, are discussed in terms of a possible antagonism of adrenal cortical hormone.
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