Abstract
Summary
Exposure of glutaraldehyde-treated red cells (GRC) to anti-red cell serum or to immune IgG increased their attachment to mouse peritoneal macrophages in saline medium. GRC treated with antibody also attached to trypsinized macrophages under conditions where the attachment of untreated GRC was very low. Use of nonimmune serum or of nonimmune IgG, as well as absorption experiments showed that the effect of anti-serum was due to antibody. The results are consistent with the hypothesis that different receptors are involved in the attachment to macrophages of GRC that have or have not been treated with antibody.
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