Abstract
Summary
The passage of cycasin and MAM through the placenta and mammary gland has been investigated in rats during pregnancy and lactation, respectively. Both cycasin and MAM cross the placenta when cycasin is given orally to pregnant rats. Both compounds can also pass the mammary gland and are excreted with the milk during lactation provided that they are administered within 1 day before littering or during lactation. MAM has also been found in the fetuses after its intravenous injection into the pregnant golden hamster. The recovery of MAM from the fetuses of rats and hamsters supports a direct action of the carcinogen and teratogen on fetal tissues.
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