Abstract
Summary
The teratogenic action of six disazo dyes was investigated in the Wistar albino rat. Appropriate dosages administered during day 8 of gestation showed the most potent teratogenic dye to be trypan blue followed by Evans blue, Niagara blue 4B, Niagara sky blue 6B, Congo red, and Niagara blue 2B. The diversity in types of malformations produced in the offspring of dye-treated mothers varied with the potency of the dye injected. Trypan blue caused the greatest number of different types of malformations and Niagara blue 2B the least. Ocular defects and hydrocephalus were the two most frequent abnormalities following treatment with each dye. There was no consistent correlation between dye action and maternal weight at the onset of treatment, maternal weight gained during pregnancy, maternal age, parity, fetal weight at autopsy, or placental weight.
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