Abstract
Conclusions
The paramitotic cytomorphological effects of colchicine are transient and probably reversible. For assay purposes, the drug can be administered either subcutaneously or intraperitoneally. The latter route increases the sensitivity of the assay by about 20 times. A single sampling at 3-4 1/2 hours is justifiable and, within reason, the choice of solvent for the drug appears of secondary importance—at least for subcutaneous injection.
It is postulated that colchicine does not act alone at the cellular level, but that it must act in concert with some extracellular (perhaps systemic) factor or factors. Some implications of this hypothesis are mentioned.
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