Abstract
Summary
The effect of interferon on the induction of deoxythymidine kinase has been studied in vaccinia-infected chick embryo and mouse cell culture systems. Antecedent treatment of vaccinia-infected chick embryo cells with interferon inhibited deoxythymidine kinase induction. The inhibitor of deoxythymidine kinase was shown to share many properties with interferon. In the presence of concentrations of cytosine arabinoside or bromodeoxyuridine which suppressed vaccinia replication, interferon effectively inhibited deoxythymidine kinase induction, indicating an interferon effect on virus prior to replication of viral DNA. These results are consistent with other studies which indicate that interferon may act to prevent the function of viral mRNA. In contrast, under similar experimental conditions, mouse interferon did not inhibit deoxythymidine kinase induction in the mouse embryo cell culture system although interferon effectively inhibited viral multiplication.
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