Abstract
Summary
The effects of thyrocalcitonin on extracellular levels of hydroxyproline were examined in the following situations which normally alter this parameter through effects on bone resorption: peritoneal lavage, parathyroidectomy, nephrectomy, and calcium restricted diet. It was found that thyrocalcitonin reduced extracellular hydroxyproline levels in all situations studied. Effects on removal of hydroxyproline and calcium by peritoneal lavage were of such magnitude to suggest that the entire process of whole bone catabolism is inhibited by thyrocalcitonin. Marked effects of thyrocalcitonin in the presence of increased levels of endogenous parathyroid hormone indicate that thyrocalcitonin can block the effects of parathyroid hormone. It is concluded that repeated administration of thyrocalcitonin results in an inhibition of all phases of bone resorption.
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