Effect of Reduced Glutathione on Erythrocyte Lipid ∗

Abstract

Summary

The data presented herein demonstrate that as normal cells incubated with GSH assume in vitro lytic features usually considered typical of PNH erythrocytes, they also lyse excessively and form greater than normal quantities of lipid peroxides when incubated with H₂O_2. The results suggest that GSH in creating the PNH-like cell ultimately affects erythrocyte lipid. These observations are consistent with our hypothesis that peroxidation of red cell lipid may be involved in the PNH corpuscular lesion.