The Cell Cycle of Leukemia L1210 Cells in vivo and in vitro. ∗

Abstract

Summary

The cell cycles of Leukemia L1210 cells proliferating in mice after serial transplantation, proliferating in mice following inoculation of cultured cells, and proliferating in vitro in spinner cultures have been examined by the method of waves of labeled mitoses following pulse exposure to thymidine-(methyl-³H). The cycles for the 3 groups of cells were essentially the same. The following mean values were obtained: T_C, 15.7 hr; T_G2, 1.5 hr; T_M, 0.5 hr; T_s, 11.7 hr; T_G1, 2.0 hr.