Abstract
Summary
After oral treatment with 10 mg chlormadinone acetate (CAP) for 5 days, the time of ovulation was examined by the detection of tubal ova in rats which came back into vaginal proestrus on day 3 after with drawal (66% of treated rats). This was compared with that of normal cyclic rats. In both control and treated rats, some animals had started ovulating at 1 AM, and nearly all of the rats had ovulated by 2 AM. The number of ova increased from 2 to 6 AM. From the evidence obtained it can be said that in CAP-treated rats the time of ovulation did not differ from that of the normal cyclic (4 days) rats, i.e., the timing of ovulation occurred in the same relation to the diurnal rhythm of lighting.
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