Abstract
Summary
Daily subcutaneous administration of concentrated preparations of crude or highly purified mouse brain interferon inhibited the multiplication of Friend virus and the development of splenomegaly in Swiss mice. Initiation of a continued interferon treatment 1 week after viral inoculation, at a time when splenic enlargement had already developed, still exerted a significant inhibitory effect on further development of splenomegaly. Interferon administration for only the 1st week after viral infection was ultimately ineffective. On histologic examination, far fewer foci of Friend cells were observed in the spleens of interferon treated mice than in the spleens of untreated mice. It was suggested that the inhibition of splenomegaly observed after repeated interferon administration was due to a continued inhibition of viral multiplication. Further evidence was presented that interferon itself was responsible for the inhibitory effects observed.
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