Abstract
Summary
The effect of Na-GCA on total plasma and tissue cholesterol levels in excretion of bile acids in the feces has been studied in rats with diabetes induced by injections of alloxan. The increase in the C/P ratio in plasma, liver and kidney produced by the alloxan is antagonized by Na-GCA if the latter compound is administered before the alloxan. Na-GCA increases output of bile acids in feces and concomitantly decreases the total plasma and tissue cholesterol content. Thus it appears that GCA increases metabolism of cholesterol to bile acids in the system studied.
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