Developmental Aspects of Glutathione Levels in Dystrophic Mice. ∗

Abstract

Summary

1. In the skeletal muscle of normal female mice, the reduced glutathione concentration decreases rapidly from the relatively high 17 day levels to the 46-112 day old normal adult female averages. 2. All the GSH muscle levels in dystrophic females are higher than in their normal littermates. 3. Normal male skeletal muscle yields higher GSH levels than normal female skeletal muscle in the same age range. 4. Comparison between normal and dystrophic males indicates no significant difference in GSH levels in skeletal muscle. 5. At present no significance can be assigned to differences in heart GSH levels for either sex. 6. Comparison with data in the literature indicates that differences in GSH levels in skeletal muscle of dystrophic and normal mice are minimal when compared with those reported in dystrophic and normal rabbits and chickens.