Abstract
Summary
Isolated myocardial strips of rabbit atrium were exposed to an oxygenated, modified Ringer-Locke's solution having various levels of Pco2, pH, and bicarbonate. Peak contraction force and maximum rate of tension development were used to evaluate myocardial contractility. Exposure to a low Pco2 and control pH environment did not cause a significant change in contractility. Myocardial performance was significantly increased by exposure to a bathing solution containing a low Pco2 and high pH. The results are interpreted to indicate that the change in pH is the significant factor in the positive inotropic response to low Pco2.
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