Abstract
Summary
The cytological effects of 16 quinone compounds were tested on Ehrlich ascites tumor cells in vivo. Of these only juglone (5-hydroxy-1.4-naphthoquinone) produced mitotic abnormalities. An accumulation of abnormal metaphase figures occurred and the cells in metaphase were prevented from entering ana-telophase. Chromosomes in prophase cells appeared diffuse and sticky. Juglone administration, either intraperitoneal or oral, caused decreases in the amount of ascitic fluid at a time that marked increases were taking place in control animals.
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