Abstract
Summary
Endotoxin was detected serially in the circulating blood of dogs with a bioassay by injecting canine plasma intravenously into New Zealand albino rabbits and simultaneously 50 μg epinephrine intradermally. The presence of rabbit dermal necrosis 24 hours later indicated the presence of endotoxin in the canine plasma. Prior to the injection of endotoxin all canine plasmas gave a negative reaction. Within 3 minutes post-endotoxin all plasmas showed a positive test. At 3 hours when the blood pressures had stabilized in 7 surviving animals no endotoxin was in the plasmas. However at 6 hours endotoxin was detected in the plasma of 6 out of 7 surviving animals. The persistence of endotoxin in the circulating blood could not be correlated with survival or death.
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