Abstract
Summary
Protein-bound iodine levels were determined on CFW mice inoculated with Moloney Leukemia Virus. When frank microscopic evidence of leukemia appeared in several animals, all inoculated animals and their controls were sacrificed. Hematoxylin and eosin sections were made from the spleen adn thymus of each animal, and the degree of microscopic involvement with leukemia noted. The difference in the mean PBI between virgin controls and virgin inoculated mice was not significant at the 5% level. Even though the mean PBI between the control animals and the inoculated animals as a group was not significant, a significant inverse correlation at the 5% level was demonstrated between the amount of leukemic involvement of the spleen or thymus and the PBI. The maximum increase in PBI occurred prior to microscopic involvement with leukemia and trended lower as microscopic evidence of splenic and thymic involvement appeared.
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