Abstract
Summary
Combined effects of OVAR-X and HYPO-X (double operations) on feed intake were studied. In addition, the effect of triple operations on mammary gland DNA was reported. While OVAR-X in addition to HYPO-X had little or no effect, OVAR-X and ADRE-X in addition to HYPO-X caused a marked initial decrease in feed intake. However, the feed intake gradually returned to the preoperative control level at longer intervals while body weight remained at a reduced level. It was suggested that the presence of 1% NaCl in the drinking water was unable to compensate for the lack of aldosterone which might have caused the initial decrease in feed intake.
With DNA as a measure of mammary gland tissue, a significant involution of the duct system from the ovariectomized level was observed following HYPO-X and triple operations. Although triple operations caused a lower DNA value than that of HYPO-X alone, there was no significant difference between the two groups. This suggests that the ovaries and adrenals are of secondary importance on maintenance of mammary glands after hypophysectomy.
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