Abstract
Summary
Isolated islets obtained 1 to 2.5 hours after injection of guinea pig anti-insulin serum into normal rats secrete insulin in vitro at an abnormally high rate in response to glucose. Twenty-four hours after induction of the insulin-deficiency, the absolute rate of insulin secretion is subnormal, but is still increased in relation to the low insulin content of these islets. This sequence of changes is seen in pancreatic tissue removed from spontaneously diabetic animals and suggests that this system could be used as a model for the study of islet function during the development of insulin-deficiency.
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