Abstract
Summary
Repeated attacks of experimental allergic encephalomyelitis (EAE) were induced in rats by 2, 3 or 4 consecutive biweekly passive transfers of living, encephalitogenic, lymphoid cells. The incidence and severity of clinical signs of EAE decreased progressively during successive attacks. A decrease in spinal cord lesions was found histologically only after the fourth transfer. Unexpectedly, the cerebellum revealed a marked increase of EAE lesions after the second, third or fourth transfers. This redistribution of lesions may be due to local blockade at the sites of original attack in the spinal cord.
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