Abstract
Summary
The intraperitoneal administration of the “P” form of PHA resulted in a marked depression of RES phagocytic activity. The alteration of phagocytosis occurred in temporal relationship to an enlargement of the spleen. In the majority of the animals hepatomegaly was also observed. Doses of PHA-P of 70-100 mg/100 g of body weight were found to be toxic to mice.
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