Abstract
Summary
A cell line has been established from a nodule of human giant and spindle cell carcinoma of the thyroid metastatic to a kidney. The culture has been maintained through more than 24 passages over a period of 1 1/2 years. Its identity as a cancer cell line was established by its growth on hetero-transplantation into immunologically tolerant rats with reproduction of the histologic appearance of the original tumor. Chromosomal studies showed a high degree of aneuploidy and polyploidy with numerous abnormalities of chromosomal form.
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