Abstract
Summary
A toxic factor was demonstrated in living and disrupted Leptospira pomona and in the supernatant fluids of cultures by alterations in the permeability of guinea pig peritoneal macrophages; the supernatant fluids also inhibited the uptake of oxygen by porcine kidney cells. Virulent and avirulent L. pomona were equally toxic. The soluble toxic factor was nondialyzable and thermolabile; it was not specifically neutralized by antiserum.
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