Relationship Between Tumor Incompatibility and Therapeutic Response. ∗

Abstract

Summary

A comparison of the histocom-patibility characteristics of S-180, S-180/MP, S-180/B₆ and ECA was carried out by transplantation techniques in 7 strains of mice. S-180/MP and S-180/B₆ appeared to be less immunogenic than S-180; ECA was less immunogenic than the two S-180 sublines. S-180/MP, S-180/B₆ and ECA appeared to have antigenic properties in common with S-180. The therapeutic effects of 6MP and KTS against S-180/B₆ were greater in C57B1/6 than in Swiss HalCR mice. The effects of 6MP and vitamin B₆ deficiency against ECA were evident only in Swiss HaICR sensitized to S-180. Thus, in this case, the effectiveness of therapeutic treatments was influenced by the degree of the host response to the tumor.