Abstract
Summary
DMSO causes ultrastructural changes in rat wound fibroblasts of dilation of the endoplasmic reticulum and diminution of ribosomes. Such features are similar to those described in the wound fibroblast of scorbutic guinea pigs. Ascorbic acid partly prevents DMSO damage. DMSO probably acts by interfering with cell membrane electron transfer systems and this may be the basis of its beneficial effect in clinical situations.
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