Abstract
Summary
The effects of transplanted “mammosomatotropic” pituitary tumors (MtTW5, or MtTW15) were determined on hypothalamic PIF content and pituitary prolactin concentration in host adrenalectomized-ovariectomized rats. The high concentration of prolactin in the blood of the tumor bearing rats significantly increased hypothalamic PIF content and reduced pituitary prolactin concentration and pituitary weight. This constitutes the first evidence that high prolactin in the blood can increase production of hypothalamic PIF, and presumably thereby depress pituitary prolactin secretion.
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