Abstract
Summary
Newborn mouse thymic cells were cultured in vitro for over 2 years and their possible malignant conversion was tested by injecting the cultured cells into newborn and adult syngeneic hosts. While no tumors grew in the adults, one tumor grew subcutaneously at the site of injection in 9 of the 40 newborns and in one newborn a tumor grew in the retroperitoneum. All tumors had identical morphological characteristics. Two of the tumors so obtained were transplanted and are at present at the 17th transplant generation.
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